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FLASH GENE
Symbol PDGFC contributors: mct/npt - updated : 23-02-2016
HGNC name platelet derived growth factor C
HGNC id 8801
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   lowly
Digestivemouth   moderately
 pharynx   moderately
Endocrineparathyroid   predominantly
Hearing/Equilibriumearinnercochlea highly
Reproductivefemale systemuterus  moderately
Respiratoryrespiratory tractlarynx  highly
Urinarykidneynephron  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone  highly
Muscularsmooth  lowly
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text kidney
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal CUB domain
  • a core motif of eight cysteines
  • C terminal PDGF cystine knot growth factor
  • HOMOLOGY
    interspecies homolog to rattus Pdgfc (85.80 pc)
    homolog to murine Pdgfc (86.96 pc)
    Homologene
    FAMILY
  • PDGF/VEGF growth factor family
  • CATEGORY signaling growth factor
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,nucleus
    basic FUNCTION
  • required in palate formation
  • growth factor regulating fibrogenic/fibrolytic genes in dermal fibroblasts
  • mediates the angiogenic and tumorigenic properties of fibroblasts associated with tumors refractory to anti-VEGF treatment (Crawford 2009)
  • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS development
    text central nervous system development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • FREM1 binds to PDGFC and this interaction regulates signalling downstream of PDGFRA
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in podocytes and in interstitial cells after injury/activation of these cells
    tumoral     --over  
    increased in Renal cell carcinomas (Choi 2009)
    Susceptibility to cleft lip/palate
    Variant & Polymorphism SNP -986T allele is associated with a significant decrease (up to 80p100) of PDGFC gene promoter activity and to to cleft lip/palate (Choi 2009)
    Candidate gene for malignant pleural mesothelioma
    Marker
    Therapy target
    ANIMAL & CELL MODELS