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FLASH GENE
Symbol SYNCRIP contributors: mct/npt - updated : 28-03-2018
HGNC name synaptotagmin binding, cytoplasmic RNA interacting protein
HGNC id 16918
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine   
 liver    
Lymphoid/Immunelymph node   highly
Nervousbrainhindbraincerebellum highly Homo sapiens
 brainlimbic systemhippocampus   Homo sapiens
Reproductivefemale systemuterus  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose  highly
Connectivebone  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • three globular RNA-recognition motifs (RRM) domains flanked by an N-terminal acid-rich acidic sequence segment domain (AcD12-97 )
  • four ribonucleoprotein domains
  • an Arg/Gly-rich region
  • an acidic domain having structural similarity to Barstar and binding to APOBEC1
  • a C-terminal domain containing an arginine-glycine-rich sequence motif (RGG/RXG box), which are located near to the N- and C-terminals, respectively
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytosolic,granule
    intracellular,nucleus,nucleoplasm
    text
  • mainly found at cell bodies, but punctate expression patterns in the proximal dendrite were also seen
  • had cytoplasmic somatodendritic pattern of expression, which was most prominent in the hippocampus and cerebellum
  • basic FUNCTION
  • regulating the splicing and /or transport of mRNAs from the nucleus to the cytoplasm
  • transported within the dendrite as a component of mRNA granules and involved in mRNA turnover in mRNA granules and in the regulation of local protein synthesis in neuronal dendrites
  • has dual functions, participating in both RNA replication and translation in Hepatitis C virus life cycle (Liu 2009)
  • specific role for SYNCRIP in neuronal morphogenesis
  • SYNCRIP-regulated CYBB mRNA degradation mediates the hypoinflammatory phase of sepsis
  • RNA-binding protein SYNCRIP is a component of the hepatocyte exosomal machinery controlling microRNA sorting
  • is a new RNA-binding proteins (RBPs) that controls the myeloid leukemia stem cell program
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • editosome complex
  • component of mRNA granule transported with inositol 1,4,5-trisphosphate receptor type 1 mRNA in neuronal dendrites
  • INTERACTION
    DNA
    RNA RNA interacting protein
    small molecule
    protein
  • APOBEC1 (interaction is regulated by the Acidic domain phosphorylation)
  • interacting with SMN2 (modulates the utilization of exon 7 in the survival motor neuron 2 (SMN2 gene)(Chen 2008)
  • POLR2A
  • cellular function for SYNCRIP in the control of dendritic development and focal adhesion formation that involves the negative regulation of RHOA synthesis and signaling
  • may participate in localization of mRNAs encoding CCDC42 signaling factors in neurites, and thereby may regulate actin dynamics and control neuronal morphogenesis
  • changes in cytosolic SYNCRIP levels contribute to cell cycle-dependent translational differences in TP53 mRNA
  • is involved in viral replication, neural morphogenesis, modulation of circadian oscillation, and the regulation of the cytidine deaminase APOBEC1
  • SYT7 interacts with Synaptotagmin-binding, cytoplasmic RNA-interacting protein (SYNCRIP)
  • possible functional connection between SYT7 and SYNCRIP proteins in Purkinje neurons
  • SYNCRIP and MSI2 interact indirectly though shared mRNA targets (SYNCRIP maintains HOXA9 translation, and MSI2 or HOXA9 overexpression rescued the effects of SYNCRIP depletion)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS