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FLASH GENE
Symbol NUCKS1 contributors: mct/npt - updated : 12-01-2010
HGNC name nuclear casein kinase and cyclin-dependent kinase substrate 1
HGNC id 29923
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouthtongue  highly
 stomach   highly
Reproductivefemale systemovary  highly
Urinarybladder   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • DNA-binding domain
  • two regions of highly charged, basic residues, which were identified as potential nuclear localization signals (NLS1 and 2), capable of translocating green fluorescent protein (GFP) into the nucleus (but NLS1 is the main nuclear localization signal) (Grundt 2007)
  • several consensus phosphorylation sites for cyclin-dependent kinases and CK-2
  • 19 phosphorylation sites (Wiœniewski 2008)
  • secondary structure low level of alpha helical content and substantial amounts of beta turn structures
    conjugated PhosphoP
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory , DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text
  • located in the nuclei in proliferating cells in interphase of the cell cycle, but was distributed throughout the cytoplasm in mitotic cells
  • distributed throughout the cytoplasm in mitotic cells and targeted to the reforming nuclei in late telophase of the cell cycle
  • basic FUNCTION
  • may have the highest ratio of modified to unmodified residues of any protein so far described (Wiœniewski 2008)
  • DNA-binding protein distributed throughout the cytoplasm in mitotic cells and targeted to the reforming nuclei in late telophase of the cell cycle
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA DNA-binding
    RNA
    small molecule
    protein
  • phosphorylated by CDK1 during mitosis of the cell cycle
  • binds to importin alpha3 and importin alpha5, suggesting that the nuclear targeting of NUCKS1 follows a receptor-mediated and energy-dependent import mechanism
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS