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Symbol ATXN10 contributors: mct - updated : 15-05-2013
HGNC name ataxin 10
HGNC id 10549
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveesophagus   highly
Endocrinethyroid   highly
Lymphoid/Immunethymus   highly
 tonsils   highly
Nervousbraindiencephalonhypothalamus  
Respiratoryrespiratory tractlarynx  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • C-terminal armadillo repeats
  • conjugated ubiquitinated
    HOMOLOGY
    interspecies homolog to murine Sca10
    Homologene
    FAMILY
  • armadillo repeat proteins
  • ataxin-10 family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nuclear envelope
    basic FUNCTION
  • playing an essential role for survival of cerebellar neurons
  • having a role in pancreatic beta cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with OGT (O-linked GlcNAc transferase)
  • interacting with GNB2 (coexpression of ataxin 10 and GNB2 potently activated the Ras-MAP kinase-Elk-1 cascade, a mechanism for inducing neuritogenesis
  • IQCB1-Ataxin10 interaction
  • PLK1 is one of ATXN10 binding partners
  • cell & other
    REGULATION
    Phosphorylated by PLK1 (PLK1 phosphorylation of Ataxin-10 influences its degradation and cytokinesis, which may provide mechanistic insight to SCA10 pathogenesis)
    ASSOCIATED DISORDERS
    corresponding disease(s) SCA10 , NPHP17
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS