basic FUNCTION
| SLIT receptor retinal axon guidance and control of midline crossing in the establishment of visual projections |
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acting as molecular guidance cue in cellular migration, |
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including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions |
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during neuronal development |
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playing a role in formation of the major forebrain commissures that continues through gestation until well after birth |
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playing a key role in mediating Robo-Slit signaling in cell-cell interactions during gangliogenesis, and in vertebrate development |
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control the development of the lateral olfactory tract |
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key role for Robo-Slit signaling in vertebrate longitudinal axon guidance and highlight the importance of context-specific guidance cues during navigation within complex pathways |
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as in other regions of the optic pathway, ROBO2 is the major receptor required for intraretinal axon guidance |
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ROBO1 and ROBO2, are critical for longitudinal axon guidance by the SLIT family of chemorepellents |
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has a distinct function in repelling neuron cell bodies from the floor plate |
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subtype-specific activity of ROBO2 regulates subcircuit morphogenesis in the trigeminal sensory system |
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is involved in the development of embryonic kidneys and the normal expression of ROBO2 can help maintain proper ureteric bud (UB) branching and glomerular morphogenesis (pMID: 22521888) |