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FLASH GENE
Symbol RAB1B contributors: mct - updated : 26-08-2016
HGNC name RAB1B, member RAS oncogene family
HGNC id 18370
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticthymus    
Cardiovascularheart    
Endocrinepancreas    
Nervousbrain    
Reproductivemale systemprostate   
Respiratorylung    
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
Lymphoid    
Muscularstriatumcardiac  
cell lineage
cell lines melanoma cells
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • ATP/GTP binding site
  • HOMOLOGY
    Homologene
    FAMILY
  • small GTPase superfamily
  • Rab-GTPase family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    basic FUNCTION
  • small GTPase, involved in transfer from ER to Golgi
  • role of RAB1B in antibacterial autophagy was independent of its role in ER-to-Golgi transport
  • is required for ER to Golgi transport and interacts with multiple effectors localized at the ER-Golgi interface
  • MTMR6 and RAB1B are involved in tube formation
  • is essential for endoplasmic reticulum-Golgi transport
  • changes in RAB1B levels modulate gene transcription, strongly suggesting that a RAB1B increase is required to elicit a secretory response
  • RAB1B is associated with ATG9A vesicles and regulates autophagosome formation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • GTP
  • protein
  • recruiting P115 to coat protein complex II (COPII) vesicles where P forms a cis-SNARE complex that promotes targeting to the Golgi apparatus
  • cellular localization of MTMR6 is regulated by RAB1B in the early secretory and autophagic pathways
  • recruits RAB1B to the Golgi network to drive malignant secretion
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS