Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol ACTR1A contributors: mct - updated : 22-12-2008
HGNC name ARP1 actin-related protein 1 homolog A, centractin alpha (yeast)
HGNC id 167
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrinethyroid   highly
Lymphoid/Immunespleen   highly
 thymus   highly
Nervousbrain   highly
Skin/Tegumentskin   highly
cells
SystemCellPubmedSpeciesStageRna symbol
Reproductivespermatid
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to yeast actin related protein 1
intraspecies paralog to ACTR1B
Homologene
FAMILY
  • actin family
  • ARP1 subfamily
  • CATEGORY motor/contractile
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,nucleus
    intracellular,nuclear envelope
    basic FUNCTION
  • regulator of cytoplasmic dynein-mediated functions
  • playing a role in transcriptional modulation of the F7 gene
  • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    text vesicles transport, biogenesis
    PATHWAY
    metabolism
    signaling
    a component
  • most abundant (8-13 copies) component of the large macromolecular complex, dynactin, actin-like microfilament backbone, required for the cytoplasmic dynein-driven movement of organelles along microtubules
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • orphan nuclear hormone receptor, interacted with two regions of the F7 5' flanking region, the hepatic nuclear factor 4 binding region (-77 to -47) and the nuclear hormone response region (-237 to -200)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS