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FLASH GENE
Symbol ENAH contributors: npt/mct/pgu - updated : 24-02-2009
HGNC name enabled homolog (Drosophila)
HGNC id 18271
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Reproductivemale systemtestis  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • ENA/VASP homology domain (EVH1) at the N terminus
  • an arg-leu-glu-rich region
  • a pro-rich profilin binding motif
  • C terminal EVH2 domain
  • HOMOLOGY
    interspecies homolog to murine enabled homolog
    ortholog to drosophila Ena
    Homologene
    FAMILY
  • Ena/VASP family
  • enabled/vasodilator-stimulated phosphoprotein family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton
    basic FUNCTION
  • regulating lamellipodial dynamics and actin network
  • actin regulatory protein involved in the control of cell motility and adhesion, and modulated during human breast carcinogenesis
  • have a role beyond anticapping activity in filopodia formation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction of the EVH1 domain with FPPPP sequence motifs found in a variety of cytoskeletal proteins, including lamellipodin, vinculin, and zyxin
  • ZYX recruits Enabled/vasodilator-stimulated phospho-proteins (ENAH/VASP) to promote actin assembly
  • interaction with ABI1 (promotes the ABL-mediated phosphorylation of ENAH by binding both ABL and ENAH)
  • by mediating intensive F-actin accumulation at the sites of cell infiltration, WASF2, WASL, and ENAH are crucial for PI3K-dependent cell invasion induced by PDGFA
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in high-risk benign breast lesions and primary and metastatic tumors
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS