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FLASH GENE
Symbol THOC1 contributors: mct/npt - updated : 06-01-2015
HGNC name THO complex 1
HGNC id 19070
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunelymph node    
Respiratoryrespiratory tractlarynx   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • death domain
  • HOMOLOGY
    Homologene
    FAMILY
  • TREX (transcription/export) complex
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    text colocalizes with splicing factors in nuclear speckle domains (Masuda 2005)
    basic FUNCTION
  • regulating transcriptional elongation and may participate in a protein complex functionally analogous to yeast TREX, physically linking elongating RNA polymerase II with RNA processing factors
  • THOC1-mediated RNP assembly contributes to the coordinated expression of genes necessary for normal differentiation and development
  • prevents R-loop formation and has a role in genome dynamics and function consistent with an evolutionary conservation of the functional connection between these mRNP biogenesis factors and genome integrity that had not been anticipated
  • ALYREF, THOC1 and DDX39B form a highly integrated unit to associate with the spliced mRNA and function in mRNA export
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • part of the TREX (transcription/export) complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • RB1
  • interaction with NXF1 through UBA domain, required to bind polyubiquitin, possibly by inducing an H4-dependent conformational change (Hobeika 2007)
  • NEDD4 functions in conjunction with other post-translational mechanisms to regulate THOC1 protein and THO activity
  • overexpression of NFE2L2 suppressed THOC1 promoter activity in an ARE-dependent manner
  • nuclear matrix protein that binds to the retinoblastoma tumor suppressor retinoblastoma protein (RB1)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    common in non-small cell lung cancer and may have prognostic significance in subgroups of patients (Yang 2008)
    tumoral     --over  
    in breast cancer and expression levels correlate with tumor size and metastatic potential(depletion of Thoc1 protein (pThoc1) in cancer cell lines compromises cell proliferation) (Li 2007)
    tumoral     --over  
    in ovarian and lung tumors
    constitutional     --over  
    can inhibit cell proliferation, induce G2/M cell cycle arrest and promote apoptosis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • is a functionally relevant molecular marker that may improve the identification of aggressive prostate cancers, potentially reducing overtreatment
  • Therapy target
    SystemTypeDisorderPubmed
    cancer  
    may provide a novel molecular target for cancer therapy
    cancerlung 
    may be used as a novel therapeutic target for human lung cancer treatment
    ANIMAL & CELL MODELS
  • murine Thoc1 deletion disrupts homeostasis within the small intestine but does not have detectable effects in other epithelial tissues such as the related mucosa of the large intestine
  • Thoc1 deletion prevents prostate cancer progression in mice, but has little effect on normal tissue