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FLASH GENE
Symbol IL36A contributors: mct - updated : 24-11-2017
HGNC name interleukin 1 family, member 6 (epsilon)
HGNC id 15562
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialbarrier/lining   
Lymphoid    
cells
SystemCellPubmedSpeciesStageRna symbol
Skin/Tegumentkeratinocyte
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text brain
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • twelve stranded beta trefoil structure
  • HOMOLOGY
    intraspecies homolog to FIL1H
    Homologene
    FAMILY
  • IL-1 family
  • CATEGORY signaling cytokine
    SUBCELLULAR LOCALIZATION
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense , inflammation
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • IL36A, IL36B, IL36G cytokines actively propagate skin inflammation via the activation of keratinocytes, APC, and, indirectly, T cells
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS