basic FUNCTION
| regulator of hypoxia-inducible factor HIF, alpha-1 subunit by hydroxyprenylation and targeting it to proteasome degradation |
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contributing in a non-redundant manner to the regulation of both HIF-1alpha and HIF-2alpha subunits, regulating the stability of the hypoxia-inducible factors (HIFs) in an oxygen-dependent manner |
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acting as an oxygen sensor, that controls this switch in skeletal muscle and determines hypoxia tolerance |
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role for EGLN2 as a positive regulator of intestinal epithelial cell apoptosis in the inflamed colon |
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EGLN2, EGLN3 control the transactivation activity of ATF4 |
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EGLN3 with EGLN1, EGLN2 are cellular oxygen sensors that can mark HIF1A for von Hippel-Lindau protein-mediated proteasomal destruction |
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responsible for posttranslational modification of prolines on specific target proteins |
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critical molecular link between oxygen sensing and cell-cycle control |
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by modulating CEP192 levels, EGLN2 thereby affects the processes of centriole duplication and centrosome maturation and contributes to the regulation of cell-cycle progression |