basic FUNCTION
| playing a role in chronic inflammatory response |
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playing a critical role in the differentiation of mononuclear myeloid precursors into functional multinucleated osteoclasts |
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regulates osteoclast multinucleation as well as resorption and migration of mature osteoclast |
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delivers intracellular signals through the adaptor TYROBP to regulate myeloid cell function both within and outside the immune system |
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expressed on newly differentiated and alternatively activated macrophages and functions to restrain macrophage activation |
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TYROBP and TREM2, with SYK are required for the cytokine-induced formation of giant cells |
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its signaling is an important pathway to promote healing of wounds in the colon where stem cell replacement is necessary |
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TREM2, triggering receptor expressed on myeloid cell-2, negatively regulates TLR responses in dendritic cells |
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regulates the rate of osteoclastogenesis, providing a mechanism for the bone pathology in Nasu-Hakola disease (PLOSL2) |
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TREM2 signaling has been shown to enhance the proliferation of osteoclast precursors via a phosphatidylinositol 3-kinase-mediated activation of AKT1 |
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ITAM molecules, FCER1G, TREM2 and TYROBP play an important role in osteoclast development and activity |
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is responsible for an unexpectedly high number of dementia cases |
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TREM2 and its signaling adaptor protein TYROBP/DAP12 play important roles in signal transduction in dendritic cells, osteoclasts, tissue macrophages, and microglia |
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involved in the anti-inflammatory response and osteoclast development |
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promotes adipogenesis and diet-induced obesity by upregulating adipogenic regulators in conjunction with inhibiting the WNT10B/CTNNB1 signaling pathway |
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key regulator of microglia activation in response to tissue damage |
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is required for promoting microglial expansion during aging and microglial response to insults of the white matter |
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TREM2 and TYROBP—possess the ability to modulate critical cellular functions via crosstalk with diverse signaling pathways |
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microglial receptor that recognizes changes in the lipid microenvironment, which may occur during APP accumulation and neuronal degeneration in Alzheimer disease (AD) |
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TREM2 protects from AD by enabling microglia to surround and alter APP plaque structure, thereby limiting neuritic damage |
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microglial receptor, involved in innate immunity |