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FLASH GENE
Symbol FBXO25 contributors: mct/npt - updated : 16-05-2011
HGNC name F-box protein 25
HGNC id 13596
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   specific Homo sapiens
Digestiveintestine   highly
 liver   highly Homo sapiens
Nervousbrain   predominantly Homo sapiens
Reproductivemale systemprostate  highly
 male systemtestis  highly
Urinarykidney   highly Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumcardiac   Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Muscularmyocyte Homo sapiens
Nervousneuron
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal, pregnancy
Text
  • placenta
  • higher in a fetal heart than an adult
  • PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a 40 AA F-box motif
  • an atypical serine residue which is crucial for the hFBX25-Skp1 binding
  • a functional F-box domain that binds to SKP1A and thereby to RBX1 and CUL1
  • HOMOLOGY
    intraspecies paralog to FBXO32
    Homologene
    FAMILY
  • F-box protein family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    text
  • nuclei-specific in cardiomyocytes
  • localizes to the nucleus as a component of the nuclear body named FANDs (FBXO25-associated nuclear domains), partially colocalizes with CUL1, SKP1, ubiquitinated proteins, and the proteasome
  • basic FUNCTION
  • brain-expressed F-box protein, invoved in phosphorylated dependent ubiquination
  • mitotic regulator, inhibiting the anaphase promoting complex (cyclosome, APC) and preventing mitotic exit in cystostatic factor (CSF) arrested eggs
  • F-box protein that serve as specificity factors for a family of ubiquitin ligases composed of s-phase-kinase associated protein 1, really interesting new gene-box 1, Cullin 1, and F-box protein (SCF1) that are involved in targeting proteins for destruction across the ubiquitin proteasome system
  • is cardiomyocyte-specific and acts as an ubiquitin E3 ligase to target cardiac specific transcription factors
  • has a physiological relevance in cardiac development
  • is a potential mitogen pathway regulator through ELK1 degradation
  • mediates ubiquitination and proteasomal degradation of ELK1 as well as the functional relevance of this effect in the cells
  • CELLULAR PROCESS cell cycle, division, mitosis
    protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • putative component of a E3 ubiquitin protein ligase complex (SCF) with SKP1, CUL1, RBX1 bringing ubiquitin conjugating enzymes to substrates recruited by F-box
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • huntingtin protein can be a target for the nuclear FBXO25 mediated ubiquitination
  • beta-actin, physically interacts through its N-terminus with FBXO25 and is enriched in the FBXO25 nuclear compartments
  • acts as an ubiquitin E3 ligase to target cardiac transcription factors including NKX2-5, ISL1, and HAND1, indicating that cardiac protein homeostasis through FBXO25 has a pivotal impact on cardiac development
  • FBXO25 interacts and mediates ubiquitination and proteasomal degradation of the ELK1 protooncogene regulator
  • mediates ELK1 degradation through the ubiquitin proteasome system and thereby plays a role in regulating the activation of ELK1 pathway in response to mitogens
  • FBXO25 directly interacts with TBX5 and NKX2-5, and controls TBX5 and NKX2-5 transcriptional activity to regulate cardiomyocyte development
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS