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FLASH GENE
Symbol FBXO6 contributors: mct - updated : 15-03-2014
HGNC name F-box protein 6
HGNC id 13585
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
Nervousbrain   highly Homo sapiens
Respiratorylung    
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Lymphoid    
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text liver
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a 40AA F-box motif
  • a C terminus homologous to that of rat Nfb42
  • HOMOLOGY
    interspecies ortholog to rattus Nfb42 (neural F-box 42kd)
    Homologene
    FAMILY F-box protein family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • phosphorylating dependent ubiquination
  • mitotic regulator, inhibiting the anaphase promoting complex (cyclosome APC) and preventing mitotic exit in cytostatic factor (CSF) arrested eggs
  • FBXO2, FBXO6 are involved in the endoplasmic reticulum-associated degradation pathway
  • FBXO2, FBXO6 are N-linked glycoprotein-specific F-box proteins
  • FBOX6 ubiquitin ligase complex is involved in the endoplasmic reticulum-associated degradation pathway by mediating the ubiquitination of glycoproteins
  • CELLULAR PROCESS cell cycle, division, mitosis
    protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component putative component of a E3 ubiquitin protein ligase complex (SCF) with SKP1, CUL1, RBX1 bringing ubiquitin conjugating enzymes to substrates recruited by F-box
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • various target proteins
  • regulates CHEK1 stability and cellular sensitivity to replication stress
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS