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FLASH GENE
Symbol MAN2A2 contributors: - updated : 17-10-2007
HGNC name mannosidase, alpha, class 2A, member 2
HGNC id 6825
EXPRESSION
Type ubiquitous
constitutive ofhousekeeping
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivepharynx   highly
Hearing/Equilibriumear   highly
Lymphoid/Immunespleen   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a short cytoplasmic tail,
  • a single transmembrane segment (TM1)
  • a large COOH-terminal catalytic domain
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    text type II transmembrane (TM) protein
    basic FUNCTION
  • alpha-mannosidase, membrane type, involved in processing of Asp-linked (N) glycans
  • catalyzing the first committed step in the biosynthesis of complex N-glycans
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS