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FLASH GENE
Symbol ADCK3 contributors: mct - updated : 02-05-2013
HGNC name aarF domain-containing protein kinase 3
HGNC id 16812
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestivemouth   highly
 stomach   highly
Lymphoid/Immunethymus   highly
Nervousbrain    
Reproductivefemale systemuterus   
 male systemprostate   
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose  highly
Muscularstriatumcardiac  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal kinase motifs
  • an ABC1-like motif
  • HOMOLOGY
    interspecies ortholog to yeast S.pombe ABC1 family (unrelated to ABC transporter)
    homolog to yeast Coq8p
    Homologene
    FAMILY
    CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    basic FUNCTION
  • potentially mediating TP53-inducible apoptosis through the mitochondrial pathway
  • having a protein kinase function in Q biosynthesis
  • CELLULAR PROCESS cell life, proliferation/growth
    cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    text supressor of cell growth inducer of apoptosis
    PATHWAY
    metabolism
    signaling
    part of the CoQ(10) biosynthetic pathways with PDSS1, PDSS2, COQ2, COQ6, COQ9
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • target of the TP53 tumor suppressor (third TP53-regulated gene in mitochondrial disorders)
  • cell & other
    REGULATION
    induced by the tumor suppressor TP53 and in response to DNA damage
    ASSOCIATED DISORDERS
    corresponding disease(s) UDCA
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS