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FLASH GENE
Symbol PAQR8 contributors: npt - updated : 13-01-2010
HGNC name progestin and adipoQ receptor family member VIII
HGNC id 15708
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon highly
 intestinesmall intestine  moderately
Nervousbrain   moderately
Reproductivemale systemtestis  moderately
Visualeye   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Nervousperipherous   
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text eye
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an extracellular N terminus
  • an intracellular C terminus
  • seven transmembrane domains
  • HOMOLOGY
    interspecies ortholog to murine Paqr8
    Homologene
    FAMILY
  • ADIPOR family
  • CATEGORY regulatory , receptor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,lysosome
    text
  • integral to membrane
  • colocalizes with a lysosomal protein cathepsin D
  • basic FUNCTION
  • involved in specialized lysosomal function (unique to brain and testis )
  • acting as a steroid membrane receptor
  • may be involved in oocyte maturation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS reproduction/sex
    text oocyte maturation
    PATHWAY
    metabolism
    signaling signal transduction
    G-protein coupled receptor protein signaling pathway
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • progesterone
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS