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FLASH GENE
Symbol RSF1 contributors: mct - updated : 24-10-2018
HGNC name remodeling and spacing factor 1
HGNC id 18118
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouthtongue   
Endocrinepancreas   highly
Lymphoid/Immunelymph node    
Reproductivefemale systemovary  highly
 female systemuteruscervix highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • PHD finger domain
  • XCD domain
  • C-terminal fragment of RSF1, which can bind PLK1, is sufficient to restore PLK1 localization
  • HOMOLOGY
    interspecies homolog to Drosophila cg8677
    Homologene
    FAMILY
  • intermediate filament family
  • CATEGORY chaperone/stress , protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,intermed filament
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome,centromere
    intracellular,nucleus,chromatin/chromosome,kinetochore
    text
  • RSF1 is enriched at mitotic centromeres
  • localizes at mitotic kinetochores and directly binds PLK1
  • basic FUNCTION
  • involved in transcription repression, transcription coactivation when associated with hepatitis B virus X protein (HBX), and chromatin remodeling and spacing when associated with SMARCA5
  • plays a role in chromatin remodeling and transcriptional regulation that may contribute to tumorigenesis in ovarian cancer
  • possesses nucleosome-dependent ATPase activity, whereas RSF1 (HBXAP) functions as a histone chaperone
  • both the full-length RSF1 and SMARCA5 were required to form a functional RSF complex responsible for the growth suppression effects
  • its increased chromatin remodeling activity induce DNA strand breaks, activate the ATM/TP53-dependent DNA damage responses, and lead to growth arrest and apoptosis in cells with wild-type TP53
  • contributes to malignant cell growth by cyclin D1 and ERK modulation
  • new function of chromatin remodeler RSF1 as a guard in DNA damage checkpoints and homologous recombination repair
  • contributes to hepatocellular carcinoma cell growth through regulation of cell cycle proteins
  • RSF1 is an essential centromeric component that recruits PLK1 to kinetochores and plays a crucial role in faithful cell division
  • role in histone H2A ubiquitination-mediated gene silencing
  • RSF1 regulates the dynamics of H2A histone modifications at mitotic centromeres and contributes to the maintenance of chromosome stability
  • is one of chromatin-remodeling factors, linked to the DNA damage response (DDR) and DNA repair
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • complexing with SMARCA5, complex participating in chromatin remodeling by mobilizing nucleosomes in several conditions, and form an ISWI chromatin remodeling complex, RSF
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with sucrose nonfermenting protein 2 homologue (SMARCA5) to form a chromatin remodeling complex that participates in several biological processes (interaction may define potentially a survival signal in those ovarian tumors overexpressing RSF1)
  • RSF1 and ATF7IP are very likely interacting with SP110 during the process of viral infections
  • affects lung cancer cell growth by regulating CCND1 expression and ERK signaling
  • RSF1 interacts and collaborates with CCNE1 in neoplastic transformation and TP53 mutations are a prerequisite for tumour-promoting functions of the RSF1/CCNE1 complex
  • RSF1 facilitates the assembly of centromere proteins CENPS and STRA13 at sites of DNA damage, while SMARCA5 was not required for these events
  • RSF1 directly binds PLK1
  • temporal regulation of RSF1 levels at its post-translational modification by SMARCA5 and ATM is essential for efficient DNA repair
  • RSF1 interacts with and recruits HDAC1 to centromeres
  • RSF1 regulates SGO1 localization to centromeres through coordinating a crosstalk between histone acetylation and phosphorylation
  • is necessary for TP53-dependent gene expression in response to DNA strand breaks via controlling the accessibility of TP53/EP300 complex to its target genes and contributes to the maintenance of cellular integrity
  • cell & other
  • interacting with and potentiated by the viral X protein to regulate NF-kappaB
  • REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    is associated with advanced clinical stage and lymph node metastasis in ovarian clear cell carcinoma
    constitutional     --over  
    promoted chromosomal instability as evidenced by increased karyotypic abnormalities and DNA copy number alterations in otherwise chromosomally stable cells
    tumoral     --over  
    in non-small cell lung cancer
    constitutional       loss of function
    RSF1 deficiency did not result in any neuropathological abnormalities, but prevented neural apoptosis triggered by excessive DNA strand breaks during neurogenesis
    tumoral     --over  
    in 41.1 p 100 of hepatocellular carcinoma correlated with poor overall survival
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • serves as a novel tumor marker in hepatocellular carcinoma
  • Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveovary
    RSF1 gene-transduced dendritic cells may be a potential adjuvant immunotherapy for ovarian cancer in clinical applications
    cancerlung 
    candidate therapeutic target in lung cancer
    ANIMAL & CELL MODELS