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FLASH GENE
Symbol TRIM69 contributors: mct - updated : 24-04-2013
HGNC name tripartite motif-containing 69
HGNC id 17857
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine  moderately
 mouth   highly
Endocrineadrenal gland   moderately
Hearing/Equilibriumearinnercochlea moderately
Lymphoid/Immunelymph node    
Nervousnervecranial nerve  predominantly
Reproductivefemale systemuterus  moderately
 male systemtestis  moderately Homo sapiensAdult
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connective   moderately
cells
SystemCellPubmedSpeciesStageRna symbol
Reproductivespermatid Mus musculusAdult
Reproductivespermatid Homo sapiensAdult
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N-terminal RING-type zinc finger motif, with 82 amino acids, a RING-consensus sequence rich in cysteine residues between amino acid 41 and 81, essential for TRIM69 localisation and aggregation
  • one or two B-boxe
  • a B30.2 domain
  • an associated coiled-coil region
  • a C terminal SPRY (SP-1a and Ryanodine receptor) domain
  • conjugated PhosphoP , MetalloP
    HOMOLOGY
    interspecies homolog to rattus Trim69 (80 pc)
    homolog to murine Trim69 (78.6 pc)
    Homologene
    FAMILY
  • C-IV TRIM family
  • RING-B-box-coiled-coil (RBCC) family
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    intracellular,nucleus,chromatin/chromosome
    text
  • nuclear localization is under the control of phosphorylation, which might be mediated by p38
  • localise in both the cytoplasm and the nucleus in a speckled aggregating pattern
  • basic FUNCTION
  • inducing cell apoptosis when overexpressed
  • may play a role in germ cell homeostasis during spermatogenesis
  • could mediate ubiquitination, which could be enhanced by a proteasome inhibitor
  • novel E3 ubiquitin ligase identified from testis and may function to ubiquitinate its particular substrates during spermatogenesis
  • displayed an E3 ubiquitin ligase activity in a RING finger domain-dependent manner
  • possesses an E3 ligase activity and might mediate the formation of multiubiquitinylated products
  • CELLULAR PROCESS cell life, cell death/apoptosis
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • colocalizes and interacts with PML (may interact with PML and induce cell apoptosis)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS