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FLASH GENE
Symbol FKBP1B contributors: - updated : 27-07-2005
HGNC name FK506 binding protein 1B, 12.6 kDa
HGNC id 3712
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/ImmuneT cell
cell lineage
cell lines Jurkat T lymphoblastoid cell line
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • rotamase N terminal FK506 binding and peptidyl prolyl cis-trans domains
  • three tetratricopeptide repeat (TPR) motifs consistent with nuclear transcript or chaperone activity
  • HOMOLOGY
    Homologene
    FAMILY immunophilin class of proteins family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • playing a role in immunoregulation and basic cellular processes involving protein folding and trafficking
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cardiovascular , immunity/defense
    text excitation-contraction coupling in cardiac muscle
    PATHWAY
    metabolism
    signaling
    a component
  • complexing with FK506-rapamycin and RYR2 (stabilizing the closed state of RYR2 and preventing the calcium leak that triggers arrhythmias)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • RYR2 in cardiac muscle sarcoplasmic reticulum, to stabilize RYR2 and preventing aberrant activation of the channel during the resting phase of the cardiac cycle
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene for treatment of heart failures (by binding to ryanodine receptors)
    Marker
    Therapy target
    ANIMAL & CELL MODELS