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FLASH GENE
Symbol FKBP14 contributors: mct - updated : 15-06-2012
HGNC name FK506 binding protein 14, 22 kDa
HGNC id 18625
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivefemale systembreastmammary gland highly
Respiratoryrespiratory tractlarynx  highly
Skin/Tegumentskin   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • rotamase N terminal FK506 binding
  • a peptidyl prolyl cis-trans isomerase domain
  • two EF-hand calcium binding domains
  • mono polymer monomer
    HOMOLOGY
    interspecies homolog to murine Fkbp7
    Homologene
    FAMILY
  • immunophilin class of proteins family
  • FK506-binding protein (FKBP)-family of peptidyl-prolyl cis-trans isomerases (PPIases)
  • CATEGORY chaperone/stress , enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,lumen
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • peptidyl-prolyl cis/trans isomerases (PPIases) that bind the immunosuppressive drug FK506
  • exhibits a chaperone as well as a PPIase activity
  • implicated in catalyzing cis-trans-isomerization of peptidyl-prolyl peptide bonds and are supposed to accelerate protein folding
  • peptidyl-prolyl cis-trans isomerases that play integral roles in protein folding, assembly and trafficking
  • plays an essential role in development, one aspect of which includes regulating members of the Notch signaling pathway
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
  • protein
  • binds via its FK506 binding protein (FKBP) domain directly to the Hsp70 chaperone HSPA5 that stimulates its chaperone activity
  • FKBP14 acts downstream of NOTCH1 activation at the membrane
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) EDS6C
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS