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FLASH GENE
Symbol FKBP11 contributors: mct - updated : 17-03-2012
HGNC name FK506 binding protein 11, 19 kDa
HGNC id 18624
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouth   highly
Endocrinepancreas   highly
Hearing/Equilibriumear   highly
Reproductivefemale systembreastmammary gland highly
Skin/Tegumentskin   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a cleavable N-terminal signal sequence followed by a putative peptidyl-prolyl cis/trans isomerase domain with homology to FKBP12
  • three tetratricopeptide repeat (TPR) motifs consistent with nuclear transcript or chaperone activity
  • HOMOLOGY
    Homologene
    FAMILY
  • immunophilin class of proteins family
  • FK506-binding protein (FKBP) family of peptidyl-prolyl cis/trans isomerases
  • CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • binding protein FKBP11 for the immunosuppressive agents FK506-rapamycin
  • intrinsic peptidyl-prolyl cis-trans isomerase activity
  • only protein it was found to interact with IFITM5 in osteoblasts, while IFITM5 interacts with several proteins in fibroblasts
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • IFITM5 forms a complex with FKBP11-CD81-PTGFRN
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction IFITM5-FKBP11 in osteoblasts, and FKBP11 was associated with CD81, which interacts with prostaglandin F2 receptor negative regulator (PTGFRN) and CD9
  • associates with CD81, which interacts with PTGFRN and CD9, resulting in the formation of a FKBP11–CD81–[PTGFRN/CD9] complex in osteoblast
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS