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FLASH GENE
Symbol ZKSCAN3 contributors: mct/pgu - updated : 23-09-2010
HGNC name zinc finger with KRAB and SCAN domains 3
HGNC id 13853
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Nervousbrain    
Reproductivemale systemprostate   
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a KRAB Krüppel-associated box at the N terminus
  • a SCAN box mediating self-association and oligomerization
  • a C2H2 Krüppel-type zinc finger domain
  • conjugated MetalloP
    HOMOLOGY
    interspecies homolog to Drosophila cg4971
    homolog to C.elegans cwn-2
    Homologene
    FAMILY
  • krueppel C2H2-type zinc-finger protein family
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • potential transcriptional regulator
  • regulates the expression of several genes favoring tumor progression including integrin beta 4
  • its induction represents a mechanism by which myeloma cells can induce cyclin D2 dysregulation, and contribute to disease pathogenesis
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • specifically bind to oligonucleotides representing sequences from the CCND2 promoter, and to the endogenous promoter itself in myeloma cells
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS