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FLASH GENE
Symbol PLSCR3 contributors: mct - updated : 10-12-2010
HGNC name phospholipid scramblase 3
HGNC id 16495
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen    
 thymus    
Cardiovascularheart    
Digestiveintestinesmall intestine   
 liver    
Endocrinepancreas    
Reproductivefemale systemuterus    Homo sapiens
 male systemprostate   
Respiratorylung    
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose   
Muscularstriatumskeletal  
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticmature hematopoietic
Lymphoid/Immunelymphocyte
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • multiple PXXP motifs
  • a PPXY motif located near the N terminus implying the potential for interaction with SH3 or WW domain containing proteins
  • a Ca2+ binding motif that is a novel type of Ca2+ binding motif
  • conjugated LipoP , PhosphoP , Other
    HOMOLOGY
    interspecies homolog to murine Plscr3
    homolog to C.elegans zk1053.5
    Homologene
    FAMILY
  • phospholipid scramblase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,membrane
    text
  • type II membrane protein
  • localized to mitochondria
  • basic FUNCTION
  • mediating calcium dependent bidirectional movement between membrane bilayers in injured,activated or apoptotic cells
  • downstream effector of PRKCD in the mitochondria
  • may play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system
  • playing an analogous role in signaling and in the cellular response to insulin
  • novel regulator of cardiolipin de novo biosynthesis and its resynthesis
  • transports CL (cardiolipin) from the inner to the outer mitochondrial membrane
  • plays an important role in regulation of mitochondrial morphology, respiratory function, and apoptotic responses
  • playing a role in adipose lipid metabolism
  • facilitate the translocation of aminophospholipids from the inner to the exterior leaf of the cell membrane
  • its expression facilitates changes in mitochondrial membrane lipids that promote the release of apoptogenic factors and consequent full activation and processing of the caspase-9 and effector caspase-3
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
  • protein
  • interaction with PRKCD (interacted with and phosphorylated phospholipid scramblase 3 (PLSCR3) after UV irradiation)
  • interacting with TNFSF10 (TNFSF10-induced activation of PKC-delta mediates regulation of the PLSCR3-induced changes in cardiolipin)
  • cell & other
    REGULATION
    Other phosphorylation by PRKCD induces PLSCR3 activation to facilitate mitochondrial targeting of BID and apoptosis
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS