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FLASH GENE
Symbol PRPF6 contributors: mct - updated : 03-12-2020
HGNC name PRP6 pre-mRNA processing factor 6 homolog (S. cerevisiae)
HGNC id 15860
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveesophagus   highly
Endocrinepancreas   highly
Skin/Tegumentskin   highly
cell lineage
cell lines
fluid/secretion lymph
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • nine HAT repeats
  • HOMOLOGY
    interspecies homolog to yeast S.pombe Prp1p/Zer1p
    homolog to yeast S.cerevisiae Prp6p
    homolog to murine Prpf6 (98.3pc)
    homolog to rattus Prpf6 (98.2pc)
    Homologene
    FAMILY
    CATEGORY RNA associated , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • subunit of the spliceosome involved in cellular transport systems
  • can function as an AR-activation function-1 -specific coactivator while mediating a transcription-splicing coupling
  • involved in pre-mRNA splicing
  • possibly acting as a bridging factor between U5 and U4/U6 snRNPs in formation of the spliceosome
  • CELLULAR PROCESS nucleotide, RNA splicing
    PHYSIOLOGICAL PROCESS mitochondrial transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • TXNL4B
  • ARAF1
  • can bind androgen receptor
  • cell & other
    REGULATION
    Other strucutural integrity of the N-terminus is required to mediate a splicing event, but is not necessary for the assembly of spliceosomes (Lützelberger 2010)
    ASSOCIATED DISORDERS
    corresponding disease(s) RP60
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS