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FLASH GENE
Symbol CHAF1A contributors: mct/npt - updated : 16-04-2008
HGNC name chromatin assembly factor 1, subunit A (p150)
HGNC id 1910
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   highly
Endocrineadrenal gland   highly
Lymphoid/Immunelymph node   highly
Nervousbrain    
Reproductivemale systemprostate   
Respiratorylung    
cell lineage
cell lines
fluid/secretion
at STAGE
cell cycle     cell cycle, G1, S, G2
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal PEST domain
  • HOMOLOGY
    interspecies homolog to murine Chaf1a
    Homologene
    FAMILY
    CATEGORY regulatory , DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • playing an essential role in eukaryotic chromatin assembly during DNA replication
  • required for efficient S-phase progression in cells, and for coupling chromatin assembly with DNA replication
  • major regulator of chromatin assembly during DNA repair
  • key factor involved in histone deposition
  • CELLULAR PROCESS nucleotide, replication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • part of the chromatin assembly factor-1 (CAF-1) complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • histone H3 and H4
  • with the replication kinase CDC7-DBF4
  • ASF1A is a highly conserved histone H3/H4 chaperone that synergizes with two other histone chaperones, CHAF1A and HIRA, in DNA synthesis-coupled and DNA synthesis-independent nucleosome assembly
  • ANGEL1 has been shown to interact with CHAF1A, which has deadenylase activity, suggesting that ANGEL1 may recruit CHAF1A in EIF4E complexes
  • cell & other
    REGULATION
    Other regulated by TSC1 and TSC2
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to glioma
    Variant & Polymorphism SNP increasing the risk of glioma
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS