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FLASH GENE

Symbol

QPCT

contributors: mct/ - updated : 15-05-2007

HGNC name	glutaminyl-peptide cyclotransferase
HGNC id	9753

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine adrenal gland       highly endocrine brain diencephalon pituitary     Endocrine pancreas       highly Skin/Tegument skin       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	several glycosylation and phosphorylation sites as well as 2 cysteine residue
	an alpha/beta scaffold akin to that of two-zinc exopeptidases

HOMOLOGY

interspecies

homolog to bovine glutaminyl cyclase

Homologene

FAMILY

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
	intracellular,nucleus

basic FUNCTION

metal-dependent transferase, catalyzing the N-terminal pyroglutamate formation of numerous hormones and peptides from their glutaminyl precursor

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

other

signaling

biosynthesis of pyroglutamyl peptides

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

inhibited by

imidazole derivatives and heterocyclic chelators

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral       loss of function by promoter region methylation in primary renal cell carcinoma

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS