basic FUNCTION
| coactivator, enhancing transcription from some Pol II promoters (vitamine D, retinoid acid, estrogen and glucocorticoid-mediated gene expression) |
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binding PABP2 and directly controling the expression of muscle-specific genes at the transcriptional level |
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may be involved in oncogenesis |
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plays independent roles in transcription elongation and pre-mRNA splicing |
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modifying gene expression by both transcriptional activation and regulation of pre-mRNA splicing |
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acts with MYC and MEN1 to promote HIV-1 Tat:P-TEFb transcription at an elongation step that is bypassed under stress |
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recruits PPIL1 into the spliceosome by a region other than the peptidylprolyl isomerase active site |
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is a nuclear protein known to regulate gene expression |
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through its ability to regulate a specific domain of BMP activity in the vertebrate embryo, SNW1 is a critical regulator of neural plate border formation and thus neural crest specification |
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transcriptional cofactor distinct from other cofactors and involved in the regulation of many cancer-related proteins |
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spliceosome subunits SNW1 and PRPF8 are essential for sister chromatid cohesion in human cells |
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facilitates likely conformational rearrangements and/or contacts that couple U1 snRNP-recognition to downstream assembly events |
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novel transcriptional regulator of the NFKB1 pathway |
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WBP11 and SNW1 promote the removal of a specific subset of introns |