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FLASH GENE
Symbol HELZ contributors: mct - updated : 07-11-2018
HGNC name helicase with zinc finger domain
HGNC id 16878
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunethymus   predominantly
Nervousbrain   predominantly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Connectivebone   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one C3H1 type zinc finger
  • a DEXD consensus domain
  • ATP/GTP-binding site motif A (P-loop)
  • HOMOLOGY
    interspecies homolog to murine Helz
    Homologene
    FAMILY DEAD-helicase superfamily
    CATEGORY enzyme , DNA associated , tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • catalyzes ATP-dependent unwinding of double-stranded DNA
  • playing a role in RNA metabolism in multiple tissues and organs with in the developing embryo
  • can inhibit growth of cancer cells
  • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism other
    signaling
    RNA metabolism
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, nucleotide,
  • zinc Zn2+ binding
  • ATP/GTP binding
  • protein
  • SMYD2, similar to SMYD3, interacts with RNA Polymerase II as well as to the RNA helicase, HELZ
  • downregulation of HELZ reduced translational initiation, resulting in the disassembly of polysomes, in a reduction of cell proliferation and hypophosphorylation of RPS6
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene loss of expression of HELZ may play a role in carcinogenesis
    Marker
    Therapy target
    ANIMAL & CELL MODELS