protein
| BUD23 is a novel regulator of chromatin structure affecting NR3C1 recruitment and function, contributing to loss of NR3C1 sensitivity in inflammation, with suppressed expression in pulmonary disease |
|
TRMT112 is the interaction partner of BUD23, and stability of BUD23 is regulated through the interaction with TRMT112 |
|
TRMT112, a small protein (COG2835) conserved in all three domains of life, interacts and activates four methyltransferases (BUD23,N6AMT1) that target different components of the translation machinery (rRNA, tRNAs, release factors) |