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FLASH GENE
Symbol SLC28A3 contributors: mct - updated : 07-04-2020
HGNC name solute carrier family 28 (sodium-coupled nucleoside transporter), member 3
HGNC id 16484
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouth    
Hearing/Equilibriumearinnercochlea   Mus musculus
Reproductivefemale systembreastmammary gland  
Respiratoryrespiratory tracttrachea   
Urinarybladder    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminus of SLC28A3 contains critical motifs implicated in trafficking
  • thirteen putative tramsmembrane helices
  • has two cation-binding sites, one of which is Na+-specific and one of which also accepts H+
  • C-terminal intramembranous cysteine residue of hCNT3 (Cys-561) that reversibly binds the hydrophilic thiol-reactive reagent p-chloromercuribenzene sulfonate (PCMBS)
  • HOMOLOGY
    interspecies homolog to murine Slc28a3
    Homologene
    FAMILY
  • SLC28A transporter family
  • concentrative nucleoside transporter (CNT) protein family
  • CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • mediate inwardly-directed Na(+)/nucleoside cotransport, being broadly selective for both pyrimidine and purine nucleosides
  • transporting a broad range of physiological purine and pyrimidine nucleosides as well as anticancer and antiviral nucleoside drugs
  • mediates transport of a broad range of purine and pyrimidine nucleosides and nucleoside drugs
  • is also capable of H(+)-mediated nucleoside cotransport
  • uses the electrochemical gradient of Na(+) and H(+) to drive the transport of nucleosides and therapeutic nucleoside analogs into the cells
  • broad-selectivity, high-affinity protein implicated in the uptake of most nucleoside-derived anticancer and antiviral drugs
  • thought to concentrate nucleosides including cytidine, uridine, adenosine and guanosine in a cell by coupling translocation of two H+ or Na+ ions per nucleoside
  • is directly involved in the metabolism of two drugs (anthracycline and gemcitabine)
  • likely specific role in the sensory epithelium of the utricle and cochlea
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • LGALS4 interacts with the drug transporter SLC28A3 to regulate its function
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    increases during gestation
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS