basic FUNCTION
| transcriptional activator, promoting cell proliferation |
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involved in the cellular response to cardiovascular injury |
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plays a key part in the pathogenesis of cardiovascular diseases such as atherosclerosis and cardiac hypertrophy and fibrosis by mediating tissue remodeling in response to external stresses |
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implicated in carcinogenesis |
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playing a key role in mediating tissue remodeling |
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binding and transactivating the TCR-Dbeta 1 promoter |
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is important for induction of PDGF-alpha chain |
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is a key regulator of adipocyte differentiation |
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acts in concert with CEBPB/CEBPD to activate the PPARG promoter |
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having a growth-promoting role in intestinal epithelium |
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regulator of lipid metabolism and its SUMOylation within transcription factor complexes that also contain PPAR- serves as a molecular switch to repress or activate genes involved in lipid catabolism in response to PPAR- ligand and other signals |
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causes cartilage matrix degradation through transcriptional induction of MMP9, providing the first evidence that transcriptional regulation of a proteinase contributes to endochondral ossification and skeletal development |
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may be indispensable for skeletal development only in the perinatal period but be dispensable after birth under physiological and pathological conditions |
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plays a central role in cardiovascular pathologies through direct and specific stimulation of cell growth as well as inhibition of apoptosis |
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regulates both apoptosis in the early phase and proliferation in the late phase, thus indicating that this factor acts as a bimodal and likely central regulator of proliferative cardiovascular pathologies |
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mediates the signaling functions in cell proliferation, cell cycle, apoptosis, migration, differentiation, and stemness by regulating gene expression in response to environment stimuli |
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may promote breast cancer cell proliferation at least partially through directly activating the FGFBP1 mRNA transcription |
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not only essential for MYC transcription in proliferating epithelial cells but also mediates the inhibitory effect of TGFbeta on MYC transcription |
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mportant transcription factor regulating cell proliferation, cell cycle, survival, migration, differentiation, angiogenesis, and stem cell self-renewal |
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multifunctional transcription factor involved in cell proliferation, differentiation and carcinogenesis |
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required for formation and differentiation of the bladder urothelium |
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promoted cancer cell proliferation, migration and invasiveness in a manner dependent partly on TNFRSF11A expression |
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KLF5 and TNFRSF11A promote cervical cancer cell proliferation, migration and invasiveness |
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CDX1/CDX2, and KLF5 are key transcription factors involved in SHH pathway and cancer stem cells |