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FLASH GENE
Symbol TACC3 contributors: mct/pgu - updated : 25-06-2013
HGNC name transforming, acidic coiled-coil containing protein 3
HGNC id 11524
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen   lowly
 thymus   highly
Digestiveintestine   lowly
Reproductivemale systemtestis  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoietic    
Lymphoid    
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticleukocyte
cell lineage hematopoietic cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • myosin tail
  • tyrosine phosphorylation site
  • C terminal coiled-coil region, 200- AA coiled coil motif, TACC domain, consisting of two functionally distinct subdomains, CC1 aa 414-530) and CC2 (aa 530-630)
  • HOMOLOGY
    interspecies homolog to murine Tacc3
    Homologene
    FAMILY
  • TACC family
  • CATEGORY adaptor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    intracellular,nuclear envelope
    text
  • perinuclear vesicles of dermal microvascular endothelial cells
  • subcellular localization at the mitotic spindle apparatus (
  • basic FUNCTION
  • involved in cell growth and differentiation, role in terminal erythropoiesis
  • playing an essential role in hematopoietic stem cell function and genetically interfacing with TP53 -regulated apoptosis
  • involved in spindle assembly and cellular survival
  • may play a role in the microtubule-dependent coupling of the nucleus and the centrosome
  • may contribute to cancer
  • involved in the process that regulate centrosome-mediated interkinetic nuclear migration of neural progenitors
  • contributes to the regulation of gene transcription
  • negative regulator of the Notch signaling pathway
  • a TACC3/CKAP5/clathrin complex stabilises kinetochore fibres by inter-microtubule bridging
  • non-motor microtubule-associated protein (MAP) that is important for mitotic spindle stability and organization
  • essential for mitotic spindle dynamics and centrosome integrity during mitosis
  • is a driver of tumorigenesis as well as an inducer of oncogenic EMT and highlight its overexpression as a potential therapeutic target for preventing EMT-associated tumor progression and invasion
  • crucial for proper mitotic spindle assembly and dynamics to prevent faulty cell division and aneuploidy
  • essential for proper kinetochore capture and kinetochore fiber formation
  • critical TACC3-dependent acentrosomal microtubule nucleation and sorting process to regulate kinetochore–microtubule connections
  • CELLULAR PROCESS cell life, differentiation
    cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule other,
    protein
  • ARNT
  • ARNT2
  • interacting with GCN5L2 and PCAF
  • centrosomal protein that interacts with CKAP5
  • specifically interacts with the NOTCH4/CDC10/Ankyrin repeats
  • binding partner for NOTCH4 that acts as a negative regulator of Notch signaling, and also binds to the other members of the Notch receptor family
  • performs its centrosome clustering activity in a focal adhesion-independent, but centrosome-dependent, manner through the microtubule regulating proteins TACC3 and CKAP5
  • CLTC binds specifically to phosphorylated TACC3 and recruits it to spindle poles for proper spindle assembly and chromosome alignment
  • at microtubules contains clathrin in addition to its previously identified binding partner CKAP5
  • adaptor that recruits CKAP5 and clathrin to mitotic microtubules, in an AURKA-regulated manner
  • DOCK7 interaction with TACC3 controls interkinetic nuclear migration and the genesis of neurons from radial glial progenitor cells during cortical development
  • TACC3 is an AURKA substrate essential in central spindle formation
  • is also a target of the RAN GTPase system, and it may coordinate with RAN to regulate acentrosomal microtubules for kinetochore capture
  • C-terminal TACC domain of TACC3 and a C-terminal fragment adjacent to the TOG domains of CKAP5 mediate the interaction between TACC and CKAP5, interaction required for spindle assembly and microtubule dynamics during mitotic cell division
  • cell & other
  • microtubules
  • REGULATION
    activated by EPO in erythroid progenitors
    Other phosphorylated by AURKA, essential for the proper localization to centrosomes and proximal mitotic spindles
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       gain of function
    in various cancer cell lines
    tumoral     --over  
    in multiple myeloma with t(4;14)(p16;q32)
    tumoral     --low  
    down-regulated by paclitaxel treatment in cervical cancer cells, overexpression of TACC3 may be associated with the mechanisms of chemoresistance, tumor progression, cell proliferation and metastasis
    tumoral     --low  
    reduced expression in follicular, papillary and anaplastic thyroid carcinomas
    tumoral fusion      
    of FGFR1 or FGFR3, to the transforming acidic coiled-coil (TACC) coding domains of TACC1 or TACC3, respectively in glioblastoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    potential therapeutic target in cancer cells
    cancerhemopathy 
    is a vulnerable component of the spindle assembly in lymphoma cells and is a promising cancer chemotherapy target
    ANIMAL & CELL MODELS