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FLASH GENE
Symbol COX7B contributors: npt/mct - updated : 06-12-2012
HGNC name cytochrome c oxidase subunit VIIb
HGNC id 2291
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Endocrineparathyroid   highly
Hearing/Equilibriumear   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • 24 AA leader sequence
  • mono polymer heteromer
    HOMOLOGY
    interspecies homolog to murine Cox7b
    Homologene
    FAMILY
  • cytochrome c oxidase VIIb family
  • CATEGORY enzyme , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,membrane
    basic FUNCTION
  • one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial
  • electron transport
  • terminal enzyme in the mitochondrial respiratory chain (oxidative phosphorylation OXPHOS), catalyzing the electron transfer from reduced cytochrome c to molecule oxygen
  • indispensable for COX assembly, COX activity, and mitochondrial respiration
  • plays a role in eye development
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS electron transport
    PATHWAY
    metabolism energetic
    signaling
    a component
  • component of the cytochrome oxidase c (ferrocytochrome c: oxygen oxidoreductase) complex
  • heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural
  • subunits encoded by nuclear genes
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MLS2
    related resource MITOP database
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS