basic FUNCTION
| playing a critical role in specific uptake and salvage of purine nucleosides in kidney and other tissues |
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may have a significant role in uptake of nucleoside drugs from the intestine and is a potential transporter target for the development of nucleoside and nucleoside-mimetic drugs |
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mediate the uptake of anticancer and some antiviral drugs and are also suitable candidates to facilitate nucleoside-derived drug uptake into hepatocytes for detoxification |
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SLC28A1, SLC28A2 are pyrimidine and purine nucleoside-selective, respectively |
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plays an important role in the absorption, disposition, and biological effects of endogenous nucleosides and nucleoside analog drugs |
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is a high-affinity adenosine transporter that may play physiological roles beyond nucleoside salvage |
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is likely to modulate extracellular adenosine and cell energy balance in neuronal tissue |
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is a purine-preferring concentrative nucleoside transporter implicated in the regulation of extracellular adenosine levels and purinergic signaling |