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FLASH GENE
Symbol CXCL16 contributors: mct - updated : 09-07-2019
HGNC name chemokine (C-X-C motif) ligand 16
HGNC id 16642
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine  highly
Lymphoid/Immunelymph node    
 spleen   highly
 thymus   highly
Nervousbrainhindbrainmedulla oblongata  
Respiratorylung    
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Lymphoid    
cells
SystemCellPubmedSpeciesStageRna symbol
Cardiovascularendothelial cell
Lymphoid/Immunemacrophage
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated GlycoP
HOMOLOGY
interspecies homolog to murine Cxcl16
Homologene
FAMILY
  • intercrine alpha (chemokine CxC) family
  • CATEGORY signaling cytokine
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    text transmembrane protein, also a soluble form, type 2 membrane protein
    basic FUNCTION
  • scavenger receptor, binding, interacting and degrading oxidized LDL
  • playing an important role in atherosclerotic lesion formation
  • co-expressed with CXCR6 by first-trimester trophoblast cells and stimulate their proliferation and invasion in an autocrine/paracrine manner
  • functions, through CXCR6, as a novel chemotactic factor for prostate cancer cells
  • plays important roles in human extravillous cytotrophoblast invasion and placentation
  • involved in the accumulation of cellular cholesterol during atherosclerotic lesion development
  • may act as a novel angiogenic factor for HUVEC (umbilical vein endothelial cells) and EPHB2 is involved as an important signaling molecule to mediate its angiogenic effects
  • critical mediator of muscle regeneration, and it suppresses the development of fibrosi
  • may play a role in matrix remodeling and ultimately in the development of heart failure
  • transmembrane chemokine combining functions of a chemokine and a scavenger receptor
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development , immunity/defense , cellular trafficking transport
    text T cell trafficking, thymocyte development
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • binding phosphatidyl serine
  • protein
  • binding oxidized lipoproteins
  • SND1 promotes angiogenesis by augmenting the production of angiogenin and CXCL16
  • decreased CXCL16–CXCR6 interaction may play a potential role in osteoclastogenesis
  • P2RX7 activation induces the rapid shedding of CXCL16 and this process involves ADAM10
  • cell & other
  • binding NK cells and a subset of memory CD4 T cells
  • REGULATION
    induced by interferon gamma
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in atherosclerotic lesions
    tumoral       gain of function
    is a common response of tumor cells to radiation, and they have important implications for the use of local radiotherapy in combination with immunotherapy
    tumoral     --over  
    in aggressive prostate cancer cells compared with the less aggressive tumor cells and benign cells
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS