basic FUNCTION
| PIP3 dependent GAP that regulates Arf, Rho and Cdc42 dependent cell activities |
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likely involved in the regulation of the cell-specific trafficking of TNFRSF10A and might thus affect the efficacy of TRAIL-induced apoptosis |
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regulator of small GTPases with both an Arf GAP and a Rho GAP domain |
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regulates the endocytic traffic of EGFR and, consequently, the rate of EGFR signal attenuation |
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controls the late steps of the endocytic trafficking of the EGFR |
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phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P(3))-dependent Arf GTPase-activating protein |
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regulates the ring size of circular dorsal ruffles through ARF1 and ARF5 |