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FLASH GENE
Symbol B3GAT3 contributors: mct - updated : 12-07-2013
HGNC name beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I)
HGNC id 923
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticthymus    
Digestiveliver   lowly
Endocrinepancreas   highly
Nervousbrain   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connective    
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
Lymphoid    
cell lineage
cell lines melanoma cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a short cytoplasmic N terminal tail
  • a hydrophobic transmembrane segment (TM1)
  • a proline rich region
  • a nucleotide binding site containing a XDD motif rather than a DXD motif
  • a C terminal catalytic domain
  • potential N glycosylation sites
  • conjugated GlycoP
    mono polymer homomer , dimer
    HOMOLOGY
    interspecies ortholog to rattus Glcatp
    Homologene
    FAMILY
  • glucuronyltransferase family 43
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    text type 2 membrane protein
    basic FUNCTION
  • glycoserine-specific glucoronyl transferase in the synthesis of the glycosaminoglycan protein linkage region of proteoglycans
  • able to control and reverse articular cartilage defects in terms of PG anabolism and GAG content associated with IL1B
  • catalyzes an initial step in the synthesis of glycosaminoglycan side chains of proteoglycans
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, cofactor,
  • Mn2+ is not only essential for its activity but is also required for cosubstrate binding
  • protein
    cell & other
    REGULATION
    inhibited by EDTA
    ASSOCIATED DISORDERS
    corresponding disease(s) LRLS
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • mice with a deletion of GlcAT-I showed remarkable reduction of the synthesis of chondroitin sulfate and heparan sulfate and embryonic lethality before the 8-cell stage because of failed cytokinesis