basic FUNCTION
| involved in cytokinesis |
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forms a link between kinetochore distribution of CENPE and the mitotic spindle checkpoint |
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important role for SEPT7 in regulating dendritic branching and dendritic-spine morphology |
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may be involved in the regulation of subcellular-compartment formation during spermiogenesis |
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may participate in the regulation of glucose transport in podocytes |
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may influence recruitment of alpha-tubulin to spindles |
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forms a very tight G interface dimer in the GDP-bound state |
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SEPTIN6 and SEPTIN7 complexes bound to F-actin regulate protein sorting during multivesicular body (MVB) biogenesis |
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SEPTIN6 and SEPTIN7 function in the spatial, temporal organization of AP3B1- and ESCRT-coated membrane domains |
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SEPT2 and SEPT7 are involved in breast carcinogenesis |
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expression of non-SUMOylatable septin variants from the SEPT6 and SEPT7 groups leads to aberrant septin bundle formation and defects in cytokinesis after furrow ingression |
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SEPTIN2, SEPTIN7, and SEPTIN9 are required for efficient bacterial invasion |