basic FUNCTION
| reducing insulin disulfide bonds in the presence of NADPH and thioredoxin reductase |
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important factor in regulating critical steps of spermiogenesis |
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may be governing the stabilization (by disulfide cross-linking) of the different structures in the developing tail of spermatids and spermatozoa |
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TXNDC2 and NME8, retain association with the spermatozoa after spermiation and potentially play an important role in regulating the redox status of the mature gamete |
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sperm-specific thioredoxins, TXNDC2 and NME8, are critically important in protecting these cells against the increases in oxidative stress associated with paternal age |