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FLASH GENE
Symbol RAB4B contributors: SGE/npt - updated : 06-04-2010
HGNC name RAB4B, member RAS oncogene family
HGNC id 9782
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   lowly
Digestiveintestinelarge intestinecolon lowly
 intestinesmall intestine  lowly
 pancreas exocrine   moderately
Lymphoid/Immunelymph node   highly
 spleen   lowly
 thymus   highly
Reproductivefemale systemovary  highly
 female systembreastmammary gland predominantly
 male systemprostate  highly
 male systemtestis  lowly
Respiratorylung   lowly
Urinarykidney   lowly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone  moderately
cells
SystemCellPubmedSpeciesStageRna symbol
not specificadipocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • Rab F motifs and Rab SF regions
  • conjugated LipoP
    HOMOLOGY
    interspecies homolog to rattus Rab4b (99.5 pc)
    homolog to murine Rab4b (99.5 pc)
    homolog to Drosophila Rab4 (75 pc)
    Homologene
    FAMILY
  • small GTPase superfamily
  • Rab family
  • RAS oncogene family
  • CATEGORY regulatory , protooncogene
    SUBCELLULAR LOCALIZATION     plasma membrane
    text lipid-anchor to the cytoplasmic side of the cell membrane
    basic FUNCTION
  • regulating vesicular trafficking pathways
  • important player in the control of SLC2A4 trafficking in adipocytes (difference in its expression in obese diabetic states could act as a compensatory effect to minimize the glucose transport defect in their adipocytes) (Kaddai 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    text vesicular trafficking
    PATHWAY
    metabolism
    signaling
    a component
  • prenylated, methylated
  • INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • GTP
  • protein
    cell & other
    REGULATION
    induced by the same regulatory machinery known to be essential for the expression of MHC class II genes
    Other regulated by a typical MHC class II-like enhancer
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to Kawasaki disease
    Variant & Polymorphism SNP
  • rs2233152 near MIA and RAB4B highly associated to Kawasaki disease
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS