basic FUNCTION
| catalyzing the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched chain oxo acids derived from oleucine, valine and isoleucine |
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contribute to the renal reabsorption of aromatic amino acids in the basolateral domain of epithelial proximal tubule cells |
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play essential roles in the reabsorption of aromatic amino acids from the epithelial cells to the blood stream in the kidney |
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involved in the bidirectional transport of aromatic AAs and iodothyronines (preferentially transports T3 even more effectively than does SLC16A2) |
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facilitates both cellular uptake and efflux of T(4) and T(3) thyroid hormones, and is at least as active a thyroid hormone transporter as SLC16A2, and both transporters facilitate iodothyronine uptake as well as efflux |