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FLASH GENE
Symbol SLC16A10 contributors: mct - updated : 24-03-2010
HGNC name solute carrier family 16, member 10 (aromatic amino acid transporter)
HGNC id 17027
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
 thymus   highly Homo sapiens
Cardiovascularheart   highly Homo sapiens
Endocrinepancreas   highly Homo sapiens
Lymphoid/Immunespleen   highly Homo sapiens
Reproductivefemale systemplacenta  highly Homo sapiens
 male systemprostate  highly Homo sapiens
Urinarykidney   highly Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal highly Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal, pregnancy
Text placenta, liver
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • twelve transmembrane spanning segments
  • a cytoplasmic loop between TM6 and TM7
  • HOMOLOGY
    interspecies homolog to rattus Tat1
    intraspecies homolog to H+ monocarboxylate transporter
    homolog to XPCT
    Homologene
    FAMILY
  • major facilitator superfamily
  • monocarboxylate porter family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    text
  • coexist with SLC7A8 in the basolateral membrane of the renal proximal tubules
  • basic FUNCTION
  • catalyzing the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched chain oxo acids derived from oleucine, valine and isoleucine
  • contribute to the renal reabsorption of aromatic amino acids in the basolateral domain of epithelial proximal tubule cells
  • play essential roles in the reabsorption of aromatic amino acids from the epithelial cells to the blood stream in the kidney
  • involved in the bidirectional transport of aromatic AAs and iodothyronines (preferentially transports T3 even more effectively than does SLC16A2)
  • facilitates both cellular uptake and efflux of T(4) and T(3) thyroid hormones, and is at least as active a thyroid hormone transporter as SLC16A2, and both transporters facilitate iodothyronine uptake as well as efflux
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text transporter for aromatic aminoacids, monocarboxylate transporter
    PATHWAY
    metabolism monocarbon
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
  • proton linked
  • protein
  • CD147
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene possibly involved in blue diaper syndrome
    Marker
    Therapy target
    ANIMAL & CELL MODELS