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FLASH GENE
Symbol TREX2 contributors: mct/npt - updated : 08-09-2009
HGNC name three prime repair exonuclease 2
HGNC id 12270
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Urinarykidney    
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period
cell cycle     cell cycle
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • three conserved exonuclease motifs with an HXAXXD sequence in the third motif
  • mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to murine Trex2
    Homologene
    FAMILY
  • exonuclease superfamily
  • TREX family
  • CATEGORY enzyme , DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • catalyzing excision of nucleoside monophosphates from 3' termini of DNA (exonuclease)
  • may be a subunit of DNA polymerase III, which does not have intrinsic exonuclease activity
  • may play a role in DNA repair
  • nonprocessive enzyme that removes nucleotides at DNA 3' termini
  • plays an important function during DNA metabolism and cellular proliferation
  • undergoes a conformational change in the active site upon DNA binding including ordering of active site residues and a shift of an active site helix (de Silva 2009)
  • CELLULAR PROCESS nucleotide, repair
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA TREX2–DNA complex has revealed new information about the interaction of this enzyme with substrate (De Silva 2009)
    RNA
    small molecule
    protein
  • with UCH37
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS