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FLASH GENE
Symbol CYP4F12 contributors: mct/npt - updated : 30-06-2010
HGNC name cytochrome P450, family 4, subfamily F, polypeptide 12
HGNC id 18857
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestiveintestinelarge intestinecolon highly
 intestinesmall intestine  highly
 liver   highly
Urinarykidney   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated HemoP
mono polymer monomer
HOMOLOGY
intraspecies homolog to CYP4F2,CYP4F3
Homologene
FAMILY
  • cytochrome P450 family
  • multigenic cytochrome P450 superfamily of mixed-function monooxygenases
    • CATEGORY enzyme , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    intracellular,cytoplasm,cytosolic,microsome
    basic FUNCTION
  • oxydizing arachidonic acid and eicosanoid
  • physiological roles of CYP4F3 and CYP4F12 in eosinophils are different (Kikuta 2007)
  • metabolically active toward inflammatory mediators and exogenous compounds such as antihistaminic drugs (Cauffiez 2004)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS electron transport
    PATHWAY
    metabolism drug , lipid/lipoprotein , other
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor, nucleotide,
  • NADPH, heme
    • protein
  • flavoprotein P450 oxidoreductase (POR)
  • interacting with NR1I2 (increased binding to NR1I2 in the presence of rifampicin) (Hariparsad 2009)
    • cell & other
    REGULATION
    Other regulated by NR1I2 (NR1I2 is involved in the regulation of CYP4F12 and along with SRC1 binds to a broad range of promoters but many of these are not inducible by rifampicin) (Hariparsad 2009)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS