basic FUNCTION
| protease inhibitor |
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although both of EPPIN domains are involved in the protein's antibacterial activity, only the Kunitz domain is required for selective protease inhibition |
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EPPIN controls sperm motility in the ejaculate by binding SEMG1, resulting in the loss of calcium, most likely through a disturbance of internal pH and an inhibition of uptake mechanisms |
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EPPIN and SEMG1 rapidly co-evolved in primates due to their critical role in the modulation of sperm motility in the semen coagulum |
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modulates the liquefaction of human semen |
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EPPIN and FN1 bind to each other in human semen and on human ejaculated spermatozoa |
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is a serine protease inhibitor expressed in male reproductive tissues |
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potential role for eppin outside of the reproductive tract and eppin may have a role in the innate immune response in the lung |