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FLASH GENE
Symbol PPP1R14A contributors: mct - updated : 06-04-2011
HGNC name protein phosphatase 1, regulatory (inhibitor) subunit 14A
HGNC id 14871
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Endocrinepancreas   highly
Nervousbrain   moderately
Reproductivemale systemprostate  moderately
Respiratorylung   moderately
Urinarykidney   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularsmooth  highly Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
Text expressed in embryonic heart
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
N terminal 67 residues highly conserved
conjugated PhosphoP
HOMOLOGY
interspecies homolog to murine Ppp1r14a
Homologene
FAMILY PP1 inhibitor family
CATEGORY protooncogene
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm
basic FUNCTION
  • phosphorylation-dependent inhibitor of myosin phosphatase
  • causes a loss of merlin function characterized by merlin (NF2) phosphorylation, Ras activation and transformation
  • with DAPK3, participate in the regulation of PRKCA and PRKCE on vascular calcium sensitivity after hemorrhagic shock
  • playing a role in the regulation of endothelial cytoskeleton
  • phosphorylation-dependent inhibitor of smooth muscle myosin light chain
  • unique phosphoprotein that specifically inhibits myosin light chain phosphatase in smooth muscle and plays an essential role in agonist-induced contraction
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PP1
  • GNB2L1 is a novel interaction partner of PPP1R14A
  • cell & other
    REGULATION
    Other phosphorylated by PKN
    cooperative increases in Ca2+ and G protein activation are required for a significant activation of total kinases that phosphorylate PPP1R14A, which together overcome PPP1R14A phosphatase activity and effectively increase the Ca2+ sensitivity of PPP1R14A phosphorylation and smooth muscle contraction
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS