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FLASH GENE
Symbol PPP1R3B contributors: mct/npt - updated : 13-04-2010
HGNC name protein phosphatase 1, regulatory (inhibitor) subunit 3B
HGNC id 14942
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestiveliver   highly
Respiratorylung    
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal highly
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an N-terminal PP1-binding motif (RVSF) motif
  • a central glycogen-binding region
  • a C-terminal binding region for phosphorylase
  • HOMOLOGY
    intraspecies homolog to PPP1R3E,PPP1R3F,PPP1R3G
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • may be contributing to the insulin-stimulated phosphatase activity in skeletal muscle
  • serine/threonine phosphatase involved in the modulation of glycogen synthesis in the liver and skeletal muscle (Dunn 2006)
  • target PP1 to glycogen and regulate its activity on enzymes of glycogen metabolism (Niimi 2007)
  • activates glycogen synthase regardless of glucose, does not regulate glycogen phosphorylase and stimulates glycogenesis in combination with insulin and glucose depletion (Montori-Grau 2007)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    glycogen metabolism
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PP1
  • cell & other
    REGULATION
    activated by insulin
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS