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FLASH GENE
Symbol PPP1R1B contributors: mct/npt - updated : 19-07-2008
HGNC name protein phosphatase 1, regulatory (inhibitor) subunit 1B
HGNC id 9287
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestine   highly
 stomach   highly
Nervousbrainbasal nucleicaudate nucleus highly
 brainforebraincerebral cortex highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Nervouscentral   
cells
SystemCellPubmedSpeciesStageRna symbol
NervousPurkinje cell
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated Other
HOMOLOGY
interspecies homolog to murine Ppp1r1b
homolog to C.elegans T23B3.5
Homologene
FAMILY
  • protein phosphatase inhibitor 1 family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text
  • mainly nuclear when Ser 97 is dephosphorylated, whereas it is preferentially cytoplasmic when phosphorylated by CNSK2A1
  • drugs of abuse and food self-administration induce nuclear accumulation in striatal neurons
  • basic FUNCTION
  • inhibitor of protein phosphatase 1 and PKA
  • playing a central role in regulating the efficacy of dopaminergic neurotransmission
  • a key factor in the phosphorylation of histone H3, a component of the nucleosomal response that is essential for gene expression
  • may be a tumor suppressor in oral premalignant and malignant lesions
  • playing a role in the interactions of dopamine and glutamate in the neostriatum
  • antiapoptotic gene in upper gastrointestinal carcinomas
  • may be a tumor suppressor in in oral premalignant and malignant lesions
  • dual-function protein kinase/phosphatase inhibitor that is involved in striatal signaling
  • pivotal integrator of information in dopaminoceptive neurons, regulating the response to neuroleptics, psychotomimetics, and drugs of abuse, and affecting striatal function and plasticity (Meyer-Lindenberg 2007)
  • might mediate multidrug resistance of gastric cancer through regulation of permeability glycoprotein (P-gp) and ZNRD1 (Hong 2007)
  • plays a pivotal role in cognitive function and possibly in the pathogenesis of schizophrenia (Meyer-Lindenberg 2007)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PP1
  • changes the usage of TRA2B dependent alternative exons in a concentration-dependent manner, suggesting that the PPP1R1B:TRA2B interaction is a molecular link between signaling pathways and pre-mRNA processing
  • cell & other
    REGULATION
    activated by CAMP dependent phosphorylation produced by dopamine stimulation
    inhibited by NMDA-induced dephosphorylation
    Other phosphorylation on threonine 75 by CDK5 leads PPP1R1B inhibitor of PKA
    phosphorylation on threonine 34 by PKA leads to PPP1R1B inhibitor of protein phosphatase 1
    regulated by glutamate in neostriatal neurons involving activation of multiple signaling cascades
    phosphorylation at threonine 34 is essential for mediating the effects of both psychostimulant and antipsychotic drugs
    regulation of its phosphorylation in striatal neurons, by cocaine and haloperidol and a variety of agents
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in leukoplakia, and oral squamous cell carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target regulation of the nuclear accumulation of PPP1R1B may be important to the functions or dysfunctions of dopamine that involve transcription-dependent long-term plasticity, including neuroleptic- and L-DOPA-induced dyskinesia, and other diseases of the basal ganglia
    ANIMAL & CELL MODELS
    Darpp 32 knockout mice