basic FUNCTION
| implicated in the control of apoptosis |
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plays a role in ricin-induced apoptosis |
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regulating heat shock protein |
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regulator of TP53 transcriptional activity, suggesting a role in the response to genotoxic stress |
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implicated in apoptosis and the protein complexes with E1A-binding protein EP300, and required for acetylation of TP53 in response to DNA damage |
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regulator of AIFM1 |
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cochaperone of the heat shock protein HSP70 that is involved in various developmental processes, cellular stress and viability |
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central regulator of the cellular content of HSP70 |
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influences the membrane integration of tail-anchored proteins using the ASNA1 pathway |
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either modulates the ASNA1 pathway in higher eukaryotes or provides an alternative fate for newly synthesised tail-anchored proteins |
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BAG6, GET4 and UBL4A facilitates tail-anchored (TA) protein capture by ASNA1 |
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ubiquitin-like protein that was originally reported to be the product of a novel gene located within the human major histocompatibility complex |
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is potentially necessary for ubiquitin-mediated degradation of newly synthesized defective polypeptides |
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BAG6 acts as an inhibitor of HAVCR2–dependent exhaustion and cell death |
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enhance the proteasomal degradation of mislocalized proteins by selectively promoting their ubiquitination |
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BAG6/SGTA cycle operates likely during protein maturation and quality control in the cytosol and that together these components dictate the fate of a specific subset of newly synthesized proteins |
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nuclear BAG6 complex is an effector in DNA damage response pathway and its phosphorylation and nuclear localization are important determinants for its function |
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plays a central role in cellular homeostasis in a diverse array of processes and is part of the heterotrimeric BAG6 complex |