Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol SEC23A contributors: mct/npt/pgu - updated : 05-11-2014
HGNC name Sec23 homolog A (S. cerevisiae)
HGNC id 10701
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouth   highly
Reproductivefemale systemuterus  highly
Respiratoryrespiratory tracttrachea  highly
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticerythroid
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period neonatal
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to rattus Sec23a (98.8pc)
homolog to murine Sec23a (99.0pc)
Homologene
FAMILY
  • SEC23/SEC24 family
  • SEC23 subfamily
  • CATEGORY transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • may be playing a role in the ER-Golgi protein trafficking
  • playing an essential role for craniofacial chondrocyte maturation
  • functioning as a SAR1-specific GTPase-activating protein that hydrolyzes the GTP bound to SAR1
  • with SEC23B, although highly related paralogous secretory COPII components, are nonredundant in erythrocyte maturation
  • plays a critical role in generating transport vesicles from the endoplasmic reticulum (ER)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    text vesicular transport from the endocytoplasmic reticulum to the Golgi apparatus
    PATHWAY
    metabolism
    signaling
    a component
  • component of COPII coat protein complex responsible for vesicle budding from the ER
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SEC13/31 complex
  • SAR1
  • during COPII assembly, SAR1A deforms the membrane and recruits the SEC23A-SEC24A complex (SEC23/24), which is the primary cargo-binding adaptor for the system
  • CFDP1, Sec23 homolog A (SEC23A), and nuclear receptor binding SET domain protein 1 (NSD1), contain consensus GTF2I binding sites in their proximal promoters
  • CREB3L2-mediated SEC23A pathway is involved in regulation of intracellular procollagen trafficking
  • target of CREB3L2 is SEC23A, one of the coat protein complex II components
  • endoplasmic reticulum stress reduces COPII vesicle formation and modifies SEC23A cycling at ER Exit Sites
  • activated CREB3L2 accelerates cartilage matrix protein secretion through the up-regulation of SEC23A, which is responsible for protein transport from the ER to the Golgi apparatus and is a target of CREB3L2
  • novel regulatory mechanisms of SOX9 for controlling the secretion of cartilage matrix proteins through the activation of CREB3L2-SEC23A signaling during chondrogenesis
  • cell & other
    REGULATION
    activated by CREB3L2
    ASSOCIATED DISORDERS
    corresponding disease(s) CLSD
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS